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| Living in an imperfect world
Life does not always go as planned. We oversleep, stub our toes, cars collide. But we adjust our schedules, limp around for a while, let off steam and, well, get on with it. Likewise, the complex cellular world of molecular machines and organelles can be full of small errors and looming catastrophes. And that too is okay because quality control mechanisms exist to edit mistakes and maintain functionality. The EMBO Journal treats readers to a series of eight reviews in its FOCUS on Quality Control. Each review, along with supplementary information and teaching materials, is available online and articles were published in three subsequent print issues (Volume 27, Numbers 2, 3 and 4). The collection highlights different aspects of cellular quality control and relevance for human diseases, including mitochondrial and ER processes, protein folding and degradation, as well as quality control in RNA and DNA metabolism. Readers will find the reviews – authored by experts in their respective fields – give numerous examples of the workings of quality control and its analysis. They can explore parallels and differences between quality control mechanisms and identify emerging issues and trends. EMBO Members have free access to The EMBO Journal via the password-protected members secure area on the EMBO website.
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